Improving how chemotherapy is delivered to cancer cells is a major concern for researchers and drug manufacturers. One of the big issues with chemotherapy is that most treatment approaches focus on the tumour itself without paying significant attention to the microenvironment surrounding the tumour. Now, investigators at Purdue University have developed new technology aimed at making it easier to deliver cancer treatment to the right “address” in the body while also easing the painful side effects of chemotherapy on patients.
This new methodology uses nanoparticles (NPs), which are considered promising carriers of drugs needed for chemotherapy to target tumours. The researchers developed a technique to prepare polyol-modified nanoparticles, so they locate cancerous cells and tumours by checking out blood vessels surrounding the tumours.
The nanoparticles interact with the vascular lining to enter tumours and destroy them. The Purdue researchers found that their method helps the nanoparticles to exit from the circulation and enter tumours and better treat cancer. They have tested the method on breast cancer and melanoma models and believe it also will prove effective for many types of cancerous tumours.