It is studied by the researchers that herbal medicine, a leaf extract from the shrub Mallotus oppositifolius, which has been used across Africa for centuries. Until now, the molecular mechanism was not completely understood. Findings from the new study—published recently in Science Advances through an article titled “Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation”— found that two components of the Mallotus leaf extract bind to a previously unrecognized binding site on KCNQ1, a potassium channel essential for controlling electrical activity in many human organs, including the heart, kidneys, gastrointestinal tract, thyroid, and pancreas.
Traditional herbal medicines used for centuries often have tangible physiologic and therapeutic value. Yet for these remedies to be successful for the masses the underlying cellular and molecular properties need to be carefully teased out and assessed for safety and effectiveness. In that vein, investigators have discovered the molecular basis for therapeutic actions of an African folk medicine used to treat a variety of illnesses and disorders including diabetes, pain, headaches, paralysis, and epilepsy.
By – Assistant Professor – Alfia Sagheer
Department of Biotechnology
Uttaranchal (P.G.) College Of Bio-Medical Sciences & Hospital
Uttaranchal College of Education
College Of Nursing UCBMSH