GRAPH THEORY AND BIOLOGICAL STRUCTURES

Before discussing today’s topic first let us know what do we know about graph theory. In mathematics, graph theory is the study of graphs, which are mathematical structures used to model pairwise relations between objects. A graph in this context is made up of vertices (also called nodes or points) which are connected by edges (also called links or lines).
The graph theory plays an important role in a wide variety of disciplines, ranging from computer science, sociology, engineering and physics, to molecular and population biology. Within the fields of biology and medicine, potential applications of network analysis include for example drug target identification, determining a protein’s or gene’s function, designing effective strategies for treating various diseases or providing early diagnosis of disorders. Protein-protein interaction (PPI) networks, biochemical networks, transcriptional regulation networks, signal transduction or metabolic networks are the highlighted network categories in systems biology often sharing characteristics and properties.

Protein-protein interaction (PPI) networks mainly hold information of how different proteins operate in coordination with others to enable the biological processes within the cell. Despite the fact that for the majority of proteins the complete sequence is already known, their molecular function is not yet fully determined.Predicting protein function is still a bottleneck in computational biology research and many experimental and computational techniques have been developed in order to infer protein function from interactions with other biomolecules. The structure which is shown here of PPI is based on graph theory.

Regulatory networks (GRNs) contain information concerning the control of gene expression in cells. This process is modulated by many variables, such as transcription factors, their post-translational modifications or association with other biomolecules. Usually, these networks use a directed graph representation in an effort to model the way that proteins and other biological molecules are involved in gene expression and try to imitate the series of events that take place in different stages of the process.

Signal transduction networks often use multi-edged directed graphs to represent a series of interactions between different bio-entities such as proteins, chemicals or macromolecules and to investigate how signal transmission is performed either from the outside to the inside of the cell, or within the cell.
So, these are some of the examples of biological structures where we use graph theory.

 

 

 

By -Assistant Professor Ms. Jyoti Sharma
DEPARTMENT: Mathametics
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