GOODPASTURE SYNDROME

GOODPASTURE SYNDROME

The Good Pasture Syndrome disease was first described by an American pathologist Ernest good pasture of Vanderbilt University in 1919 and was later named in his honour. Good pasture syndrome also known as ant glomerular basement membrane disease, is a rare autoimmune disease in which antibodies attack the basement membrane in lungs and kidneys, leading to bleeding from the lungs, glomerulonephritis and kidney failure. Good pasture syndrome may quickly result in permanent lung and kidney damage, often leading to death. The ant glomerular basement membrane antibodies primarily attack the kidneys or lungs, although generalized symptoms like malaise weight loss, fatigue, fever and chills are also common, as are joint aches or pains. Around 60-80% of those with the condition experience both lung and kidney involvement s20-40% have kidney involvement alone, and less than 10% have lung involvement alone. Lungs symptoms usually coughing up blood, chest pain or shortness of breath. Kidney symptoms usually include blood in the urine, protein in the urine, unexplained swelling of limbs or face, high amounts of urea in the blood, and high blood pressure. In good pasture syndrome, ant glomerular basement membrane antibodies are produced and circulated throughout the bloodstream, damaging the membrane lining as well as targeting their capillaries.

 

 

By -ASSISTANT PROFESSOR Ms. ANAMIKA OJHA
DEPARTMENT :MICROBIOLOGY
UCBMSH Magazine – (YouthRainBow)
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