Zollinger Ellison Syndrome

Zollinger Ellison Syndrome

Zollinger Ellison Syndrome refers to rare disease in which tumors develop in pancreas and duodenum and produce high amount of gastrin which is one of the invasive factor and stimulate HCl secretion in stomach .In normal condition gastrin release HCl after intake of food to digest food.But high gastrin stimulate increased release of Hcl that lead to ulcer formation in duodenum and other parts of intestine.Tumors may become cancerous in long run and may become malignant and can affect other organs like heart and kidney.

Exact etiology is still unknown for the scientists . 25-30% of gastrinomas occur due to genetic inheritance of MEN-1 (Multiple Endocrine Neoplasia Type 1) which cause hormone releasing tumor in duodenum & endocrine gland.Though anyone can get ZES but child of parent having history of ZES more prone to develop.Occurence is very rare 1 in 1million people. Common in age group of 30-60yrs men.
Symptoms: Mild or radiating pain between navel and chest when stomach is empty or between meal which may last from 5 minutes to 1 hr along with it other symptoms include :
• Abdominal Pain
• Burping
• Hyperacidity
• Nausea
• Vomiting
• Weight loss
• Poor appetite

Treatment include medication of Proton Pump Inhibitor class that reduce HCl secretion i.e Omeprazole, Esomeprazole, Lanseprazole, Panteprazole etc. If couldn’t be controlled with medication surgical removal of tumors is the last option until it spread to other parts of the body.

By -ASSISTANT PROFESSOR- Ms. DEEPTI M SATI
Department – PHARMACOLOGY
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